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Murali Krishnan, M.
- Synthesis, Characterisation, DNA Binding/Cleavage, Anticancer and Antimicrobial Activity of Ternary Copper(II) Complexes
Abstract Views :644 |
PDF Views:5
Authors
Affiliations
1 Department of Chemistry, Thiruvalluvar University, Vellore – 632 115, Tamilnadu, IN
2 Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam – 638 401, Tamilnadu, IN
1 Department of Chemistry, Thiruvalluvar University, Vellore – 632 115, Tamilnadu, IN
2 Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam – 638 401, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 10, No 3 (2017), Pagination: 312-318Abstract
Ternary copper(II) complexes [Cu(L-Ser)(HB)(U)](ClO4) (1 and 2) where L-Ser = L-Serine, U = Urea, HB is a N,N-donor heterocyclic bases, viz. 1,10-phenanthroline (phen) (1), 2,2'- bipyridine (bpy) (2), are synthesized, characterized, and their DNA binding, cleavage and antimicrobial activities are studied. The one-electron paramagnetic complexes display a d-d band near 600 nm in water. Binding interactions of the complexes with calf thymus (CT) DNA have been investigated by absorption, emission, viscosity, and cyclic voltammetry studies. The complexes cleave the supercoiled DNA (pBR 322) to its nicked circular form in the presence of gallic acid at appropriate complexes concentration. The phen complex (1) displays significant binding propensity to the CT DNA. The bpy complex (2) does not show any significant binding to the DNA and hence poor cleavage efficiency.Keywords
1,10-Phenanthroline, 2,2’-Bipyridine, Copper, DNA Binding, MTT Assay.
- Quality of Work Life Among Employees in Textile Industry with Reference to Coimbatore District
Abstract Views :179 |
PDF Views:0
Authors
Affiliations
1 Department of Management Studies, Dr. N.G.P. Institute of Technology, Coimbatore, IN
2 Department of Management Studies, Dr. N.G.P. Arts and Science College, Coimbatore, IN
1 Department of Management Studies, Dr. N.G.P. Institute of Technology, Coimbatore, IN
2 Department of Management Studies, Dr. N.G.P. Arts and Science College, Coimbatore, IN
Source
Asian Journal of Management, Vol 8, No 3 (2017), Pagination: 572-576Abstract
Work is an integral part of everyday life, as it is our livelihood or career or business. On an average we spent twelve hours daily life and it is the one third of our entire life. Research on quality of work life is considered to be more important at the individual and organization level. Quality of work life is considered for both the employees and organization and it is involved with job satisfaction, productivity, job involvement, work environment, training and development, compensation and rewards, facilities, job enrichment etc. The success of any organisation is highly dependent on how it attracts recruits, motivates, and retains its workforce.
Today's organisation needs to be more flexible. So that they are equipped to develop their workforce and enjoy their commitment. This study is made attempt to analyses the “Quality of work life among the employees at textile industry with reference to Coimbatore District”. In order to improve quality of work life among the employees, various coping techniques have been suggested to upgrade the employee’s attitude towards their job and the working environment in the organization.
Keywords
Work Life, Working Environment, Textile Industry, Quality, Job Involvement.References
- Baba, VV and Jamal, M (1991) Routinisation of job context and job content as related to employees quality of working life: a study of psychiatric nurses. Journal of organizational behavior. 12. 379-386.
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- Edwards, J., Van Laar, D.L. and Easton, S. (2009). The Work-Related Quality of Life (WRQoL) scale for Higher Education Employees. Quality in Higher Education. 15: 3, 207-219.
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- DNA Binding And Antimicrobial Activity of Cobalt (III) Complex Containing 2,2’ Bipyridyl and 8-Hydroxy Quinoline as Ligands
Abstract Views :181 |
PDF Views:0
Authors
Affiliations
1 Department of Chemistry, Thiruvalluvar University, Vellore – 632115. Tamilnadu, IN
2 Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam - 638401. Tamilnadu, IN
1 Department of Chemistry, Thiruvalluvar University, Vellore – 632115. Tamilnadu, IN
2 Department of Chemistry, Bannari Amman Institute of Technology, Sathyamangalam - 638401. Tamilnadu, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 2 (2019), Pagination: 472-476Abstract
In this paper cobalt complex of type [Co(Bipy)2(8HQ)](ClO4)2 [Bipy = 2,2’-bipyridyl, HQ = 8-Hydroxy Quinoline) has been synthesized and characterized by elemental analyses, NMR, UV-visible, infrared spectral studies. DNA binding properties of this metal complex was investigated using absorption spectroscopy, fluorescence spectroscopy, viscosity measurements and cyclic voltammetry. The experimental results indicate that the complex bind to DNA through an intercalative mode. The complex tested for biological activity and it has good antibacterial and antifungal activity on comparing with standard drugs.Keywords
DNA Binding, Cobalt(III) Complex, Antimicrobial Activity, 8-Hydroxy Quinoline.References
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- Baskaran S, Murali Krishnan M, Arumugham MN. Synthesis, crystal structure, DNA binding, cleavage and cytotxicity, antimicrobial activity of new copper(II) complex with L-ornithine and 1,10-phenanthroline. Inorganic and Nano-Metal Chemistry. 47, 2017, 269-277.
- Saravanan PC, Murali Krishnan M, Arumugham MN. DNA Binding and Biological Activities of Ternary Copper(II) Complexes Containing L-valine and Urea. Indian Journal of Advances Chemical Science. 5, 2017, 1-6.
- Navarro M, Cisneros-Fajardo EJ, Sierralta A, Fernández-Mestre M, Silva P, Arrieche D, Marchán E. Design of copper DNA intercalators with leishmanicidal activity. Journal of Biological Inorganic Chemistry. 8, 2003, 401-408.
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- Zeng YB, Yang N, Sheng Liu W, Tang N. Synthesis, characterization and DNA-binding properties of La(III) complex of chrysin. Journal of Inorganic Biochemistry. 97, 2003, 258-264.
- Mahadevan S, Palaniandavar M. Spectroscopic and voltammetric studies of copper(II) complexes of bis(pyrid-2-yl)-di/trithia ligands bound to calf thymus DNA. Inorganica Chimica Acta. 254, 1997, 291-302.
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- Baskaran S, Murali Krishnan M, Arumugham MN, Rakesh Kumar. Synthesis and DNA studies of a copper(II) complex of 5,6-dihydro-5,6-epoxy-1,10-phenanthroline. Journal of Coordination Chemistry. 68, 2015, 4395-4407.
- Baskaran S, Murali Krishnan M, Arumugham MN, Rakesh Kumar. DFT analysis and DNA binding, cleavage of copper(II) complexes. Journal of Molecular Liquids. 221, 2016, 1045-1053.
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- Dhakshanamoorthy S, Murali Krishnan M, Arumugham MN. Synthesis, Characterisation, DNA Binding/Cleavage, Anticancer and Antimicrobial Activity of Ternary Copper(II) Complexes. Asian Journal of Research in Chemistry. 10, 2017, 312-318.
- Ezhilarasan D, Murali Krishnan M, Arumugham MN. DNA Binding / Cleavage and Antimicrobial Activity of Copper(II) Complexes Containing L-methionine and Urea. Journal of Chemistry and Chemical Sciences. 7, 2017, 477-485.
- Dhakshanamoorthy S, Murali Krishnan M, Arumugham MN. DNA Binding/Cleavage Studies of Copper(II) Complexes Containing Heterocyclic Bases, L-Serine and Semicarbazide. International Journal of Chemical and Physical Sciences. 6, 2017, 39-47.
- Sivakumar K, Komathi V, Murali Krishnan M. Dinitrophenylhydrazine: β-cyclodextrin inclusion complex as a novel fluorescent chemosensor probe for Ce4+. Research on Chemical Intermediates. 2018, 1-27, https://doi.org/10.1007/s1116.
- Sivakumar K. Parinamachivayam G, Murali Krishnan M, Chakravarty C, Bharathi A. Preparation, characterization and molecular modeling studies of the beta-cyclodextrin inclusion complex with benzoguanamine and its analytical application as chemosensor for the selective sensing of Ce4+. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 200, 2018, 212-225.
- Li J, Dong J, Cui H, Xu T, Li L. A copper(II) complex of the Schiff base from L-valine and 2-hydroxy-1- naphthalidene plus 1,10-phenanthroline: synthesis, crystal structure and DNA interaction. Transition Metal Chemistry. 37, 2012, 175-182.
- Gopinathan H, Komathi N, Arumugham MN. Synthesis, structure, DNA binding, cleavage and biological activity of cobalt (III) complexes derived from triethylenetetramine and 1,10 phenanthroline ligands. Inorganica Chimica Acta. 416, 2014, 93-101.
- Chen YQ. Synthesis, characterization, bioactivities of copper complexes with N-allyl di(picolyl)amine. Spectrochimica Acta A: Molecular Biomolecular Spectroscopy. 75, 2010, 355-360.
- Grueso E, López-Pérez G, Castellano M, Prado-Gotor R. Thermodynamic and structural study of phenanthroline derivative ruthenium complex/DNA interactions: Probing partial intercalation and binding properties. Journal of Inorganic Biochemistry. 106, 2012, 1-9.
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- Satyanarayana S, Dabrowiak JC, Chaires JB. Neither .DELTA.- nor .LAMBDA.-tris(phenanthroline)ruthenium(II) binds to DNA by classical intercalation. Biochemistry. 31, 1992, 9319.
- Haq I, Lincoln P, Suh D, Norden B, Chowdhry BZ, Chaires JB. Interaction of DELTA.- and LAMBDA [Ru(phen)2DPPZ]2+ with DNA: A Calorimetric and Equilibrium Binding Study. Journal of American Chemical Society. 17, 1995, 4788.
- Carter M, Rodriguez M, Bar AJ. Voltammetric studies of the interaction of metal chelates with DNA. Tris-chelated Complexes of cobalt (III) and iron (II) with 1,10-phenanthroline and 2,2'-bipyridine. Journal of American Chemical Society. 111, 1989, 8901.
- Santhakumar P, Arumugham MN. Synthesis, characterization of copper (II) complex with mixed ligands of 1,10-phenanthroline, L-phenylalanine and ethylamine: studies on DNA binding, nuclease and biological activities. International Journal of Recent Scientific Research. 3, 2012, 459-466.
- Robertazzi A, Magistrato A, de Hood P, Carloni P, Reedijk J. Density Functional Theory Studies on Copper Phenanthroline Complexes. Inorganic Chemistry. 46, 2007, 5873-5881.
- Dhakshanamoorthy, Murali Krishnan M, Arumugham MN. Ternary copper(II) complexes containing thiosemicarbazide: DNA binding, antimicrobial activities and DFT study. Indian Journal of Advances in Chemical Science. 6, 2018, 53-58.
- Murali Krishnan M, Baskaran S, Arumugham MN. Photochemical and DFT/TD-DFT study of trifluoroethoxy substituted asymmetric metal-free and copper(II) phthalocyanines. Journal of Fluorine Chemistry. 202, 2017, 1-8.